Here’s a long, detailed guide to in San Diego — covering its origins, menu highlights, locations, vibe, and why it’s a local favorite. 1. Overview & Concept Lefty’s Pizza is a San Diego–based pizzeria known for Chicago-style deep dish and thin crust tavern-style pizza . Founded by a Chicago native (hence the “Lefty” – a nickname), the shop brings authentic Midwest pizza traditions to Southern California. It’s often cited as one of the best deep dish spots outside of Illinois.