The short answer is: . But it comes with serious caveats.
Think of a portable Unreal Engine as a , not a production workhorse. Keep your main project on internal storage, but carry a portable copy of UE for demos, emergency fixes, or collaborative lab environments. Have you tried running Unreal Engine from an external drive? Share your experience (or horror stories) in the comments below. This post was tested with Unreal Engine 5.4.3 on Windows 11 with a Samsung T7 Shield (USB 3.2) and a Thunderbolt 4 NVMe enclosure. Your mileage may vary. unreal engine portable
Unreal Engine Portable: Can You Really Run UE5 From an External Drive? The short answer is: